(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Dermatitis--Contact

Topics: Administration, Topical; Adolescent; Adrenal Glands; Adult; Anti-Inflammatory Agents; Beclomethasone; Clinical Trials as Topic; Dermatitis; Dermatitis, Contact; Dermatitis, Exfoliative; Dermatitis, Seborrheic; Eczema; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Middle Aged; Propionates; Time Factors

Drug repurposing or repositioning (DR) refers to finding new therapeutic applications for existing drugs. Current computational DR methods face data representation and negative data sampling challenges. Although retrospective studies attempt to operate various representations, it is a crucial step for an accurate prediction to aggregate these features and bring the associations between drugs and diseases into a unified latent space. In addition, the number of unknown associations between drugs and diseases, which is considered negative data, is much higher than the number of known associations, or positive data, leading to an imbalanced dataset. In this regard, we propose the DrugRep-KG method, which applies a knowledge graph embedding approach for representing drugs and diseases, to address these challenges. Despite the typical DR methods that consider all unknown drug-disease associations as negative data, we select a subset of unknown associations, provided the disease occurs because of an adverse reaction to a drug. DrugRep-KG has been evaluated based on different settings and achieves an AUC-ROC (area under the receiver operating characteristic curve) of 90.83% and an AUC-PR (area under the precision-recall curve) of 90.10%, which are higher than in previous works. Besides, we checked the performance of our framework in finding potential drugs for coronavirus infection and skin-related diseases: contact dermatitis and atopic eczema. DrugRep-KG predicted beclomethasone for contact dermatitis, and fluorometholone, clocortolone, fluocinonide, and beclomethasone for atopic eczema, all of which have previously been proven to be effective in other studies. Fluorometholone for contact dermatitis is a novel suggestion by DrugRep-KG that should be validated experimentally. DrugRep-KG also predicted the associations between COVID-19 and potential treatments suggested by DrugBank, in addition to new drug candidates provided with experimental evidence. The data and code underlying this article are available at https://github.com/CBRC-lab/DrugRep-KG.

Topics: Algorithms; Beclomethasone; COVID-19; Dermatitis, Atopic; Dermatitis, Contact; Drug Repositioning; Fluorometholone; Humans; Pattern Recognition, Automated; Retrospective Studies

Most studies investigating steroid allergy have been performed with tixocortol pivalate, hydrocortisone butyrate and budesonide. Betnovate and Dermovate are widely prescribed in the U.K. but little is known about the frequency of sensitization to them.. To determine the optimum method to detect contact allergy to betamethasone valerate (BV) and clobetasol propionate (CP).. Seven centres tested consecutive patients attending for investigation of suspected allergic contact dermatitis to these steroids at a range of concentrations in different vehicles.. Of 1562 patients tested, 16 (1%) reacted to either BV or CP. Ten patients (0.7%) reacted to BV and 13 (0.8%) to CP. Two patients of a further centre were included in analysis of dilutions and vehicles. Sixteen of a total of 25 reactions (64%) were identified with a 1% dilution in ethanol.. Consideration should be given to adding BV and CP to a standard allergy series, given that both are frequently used in the treatment of eczema and that most patients sensitized to them are not identified with currently used markers of steroid allergy. If patch tests to BV and CP are initially negative, but an allergy is suspected, the patient should be further investigated. Further studies are required to identify the ideal patch test material.

Topics: Adult; Aged; Aged, 80 and over; Beclomethasone; Clobetasol; Dermatitis, Contact; Drug Hypersensitivity; Ethanol; False Negative Reactions; Female; Glucocorticoids; Humans; Male; Middle Aged; Patch Tests; Predictive Value of Tests; Prevalence

Topics: Administration, Cutaneous; Aerosols; Beclomethasone; Clonidine; Dermatitis, Contact; Humans

Forty patients with skin diseases were treated by the simultaneous application of three creams, the respective bases of which were beclomethasone dipropionate, sodium fusidate and ketoconazole. The treatment yielded positive results in 92.5% of the treated cases with good relief of symptoms, arrest of growth of pathogenic agents, and good local and systemic tolerance. No adverse reactions of any kind were observed.

Topics: Administration, Topical; Adolescent; Adult; Aged; Bacterial Infections; Beclomethasone; Child; Dermatitis, Contact; Dermatomycoses; Drug Combinations; Female; Fusidic Acid; Humans; Ketoconazole; Male; Middle Aged; Skin Diseases; Skin Diseases, Infectious

Topics: Adolescent; Adult; Aged; Beclomethasone; Child; Child, Preschool; Dermatitis; Dermatitis, Contact; Female; Humans; Male; Middle Aged